Produção de não-tecido por eletrofiação para análise de dissolução rápida de paracetamol em nanofibras de poli(1-vinilpirrolidona)-co-(acetato de vinila)

Abstract

The study investigates ways to improve the dissolution of paracetamol for patients with swallowing difficulties, using the sublingual administration of the drug in a non-woven format, which allows rapid release and avoids the need to swallow and chew. The electrospinning technique was applied to incorporate paracetamol (PCM) into the polymer poly(1-vinylpyrrolidone)-co-(vinyl acetate) (PVP/VA), which reduces the crystallinity of the drug, promoting an amorphous form of greater availability. The study included characterization of the electrospinning solution (viscosity and conductivity) and the resulting fibers, using scanning electron microscopy (SEM) for morphological analysis, Fourier transform infrared spectroscopy (FTIR) for identification of functional groups, differential scanning calorimetry DSC and Thermogravimetric analysis TGA for thermal properties, and X-ray diffraction (XRD) to evaluate crystallinity. The release test was performed on artificial saliva to check the dissolution time. Results indicate that higher concentration of PCM in fibers increases crystallinity, while lower concentrations result in amorphous fiber degrading more easily due to the disordered molecular state. Therefore, nonwovens with more concentrated PCM present the presence of crystallinity, as a result of the dissolution of PCM also promotes rapid dissolution of PCM in sublingual formulations, offering a promising alternative to improve the bioavailability of the drug and expanding its accessibility for patients with swallowing difficulties.