Desenvolvimento de gel antimicrobiano utilizando como princípio ativo vidros borofosfato de potássio

Abstract

Herein we report the synthesis of metal-free potassium borophosphate glasses and their application as bactericidal and bacteriostatic material. The antimicrobial activity was achieved through a simple change in the molar ratio of boron and phosphorus atoms, making borophosphate glass soluble in water. The glasses were analyzed by X-ray powder diffraction, Raman spectroscopy, laser-induced breakdown spectroscopy, and water absorption. The addition of a boron compound is required to obtain potassium-based phosphate glasses. Moreover, the change in the P/B ratio a_ects the glass solubilization in water, which increases with the phosphorus content. These borophosphate glasses were employed in the development of hydrogel formulations. These materials were submitted to tests of biological activity against the bacteria Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Phosphorous-rich samples at a concentration of 15% showed better antimicrobial activity against S. aureus and E.coli, when compared to other samples, including commercial alcohol hand sanitizer gel, with an average size of the inhibition halo of 24,02 ±1,43 and 19,24 ±1,63 mm, respectively.