@MASTERSTHESIS{ 2026:565969233,
 	title = {Curcumin supplementation and changes over time in metabolic, inflammatory, and oxidative stress markers in people living with HIV and dyslipidemia: a randomized double-blind crossover trial},
 	year = {2026},
 	url = "https://tede.unioeste.br/handle/tede/8402",
 	abstract = "People living with HIV (PLHIV) present persistent immune activation, oxidative 
 stress, and a high prevalence of metabolic disturbances, including dyslipidemia, 
 which increase cardiovascular risk. Curcumin, a polyphenolic compound derived 
 from Curcuma longa, exhibits antioxidant and anti-inflammatory properties and may 
 represent an adjuvant strategy for redox and metabolic modulation. This study 
 evaluated the effects of curcumin supplementation on metabolic, inflammatory, and 
 oxidative stress markers in PLHIV with dyslipidemia. A randomized, double-blind, 
 placebo-controlled crossover clinical trial was conducted at a specialized HIV care 
 service in southern Brazil. Adults receiving stable antiretroviral therapy for at least 
 six months and diagnosed with dyslipidemia received curcumin (1000 mg/day) or 
 placebo during two intervention periods separated by a washout phase. Biochemical 
 outcomes included lipid profile, liver enzymes, glucose, inflammatory cytokines (IL
 6, IL-10, TNF-α), and oxidative stress markers [thiobarbituric acid reactive 
 substances (TBARS) and total antioxidant capacity (TAC)]. Data were analyzed 
 using repeated-measures ANOVA assessing group, time, and group × time 
 interaction. Sixteen participants were included (mean age 44.7 ± 1.2 years; 68.8% 
 female), with adequate adherence. A significant group × time interaction was 
 observed only for total cholesterol (p = 0.034). Significant time effects were identified 
 for HDL-cholesterol (p = 0.004), triglycerides (p = 0.003), AST (p = 0.021), glycated 
 hemoglobin (p = 0.014), plasma TBARS (p = 0.049), and TAC (p = 0.003). 
 Reductions in triglycerides and TBARS and increased antioxidant capacity were 
 observed throughout the follow-up, regardless of intervention sequence. 
 Inflammatory cytokines showed marked interindividual variability. Curcumin 
 supplementation was associated with longitudinal changes in oxidative stress and 
 metabolic markers, although treatment-specific effects versus placebo were limited. 
 Larger trials with predefined oxidative endpoints are needed to confirm these 
 findings.",
 	publisher = {Universidade Estadual do Oeste do Paraná},
 	scholl = {Programa de Pós-Graduação em Ciências Aplicadas à Saúde},
 	note = {Centro de Ciências da Saúde}
}