@MASTERSTHESIS{ 2025:2724181,
 	title = {Salivary nitric oxide metabolites as a biomarker for recurrence in obese patients with breast cancer},
 	year = {2025},
 	url = "https://tede.unioeste.br/handle/tede/7928",
 	abstract = "Breast cancer (BC) is the most common neoplasia diagnosed in women 
 worldwide. Methods that are considered less invasive and may be able to provide 
 early detection are being studied, such as the use of saliva. In this context, this study 
 evaluated the levels of nitric oxide metabolites (NOx), a biomarker of oxidative 
 stress widely linked to disease development and progression, in saliva samples of 
 women with BC (n = 129) and a control healthy group (n = 200). Also, we determined 
 the relationship between NOx levels and clinicopathological parameters. Salivary 
 NOx levels were determined by the cadmium-copper-Griess method. In relation to 
 the clinicopathological categorization (age at diagnosis; menopause at diagnosis; 
 body mass index (BMI); histological; estrogen receptor; progesterone receptor; 
 HER2 receptor; cell proliferation index - Ki-67; histological grade; clots; lymph node 
 metastasis; distant metastasis; chemoresistance; recurrence) of the BC group, no 
 significant differences were found. Subsequently, the BMI of the patients with breast 
 cancer was assessed in relation to the other parameters, and a significant difference 
 was found in the recurrence parameter for overweight women, with a p-value of 
 0.035. Saliva is not yet used in the diagnosis and monitoring of patients with breast 
 cancer, so these results provide information for new studies that analyze salivary 
 NOx for its potential application as a biomarker.",
 	publisher = {Universidade Estadual do Oeste do Paraná},
 	scholl = {Programa de Pós-Graduação em Ciências Aplicadas à Saúde},
 	note = {Centro de Ciências da Saúde}
}