TEDE Collection:

Terapia Fotodinâmica em pacientes diabéticos tipo 2 com doença periodontal - ensaio clínico randomizado boca dividida.

Sun, 05 Oct 2025 00:00:00 GMT

Title: Terapia Fotodinâmica em pacientes diabéticos tipo 2 com doença periodontal - ensaio clínico randomizado boca dividida. Autor: Bezerra, Thayná Nathally Petry de Paula Primeiro orientador: Nassar, Carlos Augusto Abstract: Introduction: Diabetic individuals with untreated periodontal disease are known to be more predisposed to glycemic imbalance and the consequent development of diabetes-related complications. Due to the impaired quality of life caused by type 2 diabetes mellitus and periodontal disease, studies are needed to investigate the relationship between the two diseases and the mechanisms involved in this association, seeking ways to minimize the consequences of these changes to individual health. Antimicrobial photodynamic therapy (aPDT) is an adjunctive treatment to scaling and root planing (SRP) that can contribute to improving periodontal outcomes, especially in patients with compromised healing, such as decompensated type 2 diabetics. Objective: To compare, through clinical analysis, the use of three aPDT applications as adjunctive therapy to non-surgical periodontal treatment of stage III and IV periodontitis in type 2 diabetic patients (T2DM). Methods: Twenty patients were evaluated in a randomized, split-mouth clinical trial. The inclusion criteria were: patients of both sexes, aged 25 to 65 years, with type 2 DM (glycated hemoglobin ≥ 7%) and Stage III or IV periodontitis. All selected patients underwent non-surgical periodontal treatment and were evaluated using clinical parameters: plaque index, probing depth, clinical attachment level, and bleeding on probing. Laboratory tests (fasting blood glucose, glycated hemoglobin, and lipid profile) were requested. In addition, gingival crevicular fluid was quantified. The side for each treatment was defined by randomization. aPDT was performed immediately after SRP and reapplied at 7 and 14 days, in combination with a low-level laser (660 nm) and methylene blue (10 mg/ml). Patients were evaluated for a total period of 12 months, comprising the periods of baseline, 3, 6, and 12 months. Results: The results demonstrate an improvement in periodontal outcomes at 3, 6, and 12 months, with no significant difference between the SRP and SRP+PDT groups. There was a statistically significant reduction in glycated hemoglobin levels during the reassessment periods compared to baseline. Conclusion: We can conclude that adjunctive PDT to SRP did not provide additional clinical benefits in periodontal parameters in this patient profile, but that basic periodontal treatment was effective in reducing glycated hemoglobin levels and, consequently, improved metabolic control. Publisher: Universidade Estadual do Oeste do Paraná Tipo do documento: Tese

EFEITOS DA FOTOBIOMODULAÇÃO E DO USO DE CREME A BASE DE SERICINA EM LESÕES EXPERIMENTAIS POR QUEIMADURA DE 2° GRAU EM RATOS WISTAR

Mon, 07 Jul 2025 00:00:00 GMT

Title: EFEITOS DA FOTOBIOMODULAÇÃO E DO USO DE CREME A BASE DE SERICINA EM LESÕES EXPERIMENTAIS POR QUEIMADURA DE 2° GRAU EM RATOS WISTAR Autor: Pradal, Lilian de Araujo Primeiro orientador: Bertolini, Gladson Ricardo Flor Abstract: Second-degree burns are among the most common skin injuries, characterized by intense pain and high sensitivity. Previous in vitro studies have shown that sericin stimulates fibroblast migration and may favor lesion re-epithelialization. Photobiomodulation, whose anti-inflammatory effect is widely recognized, also presents therapeutic potential. Thus, both the isolated use of each of these approaches and their association were analyzed, with the objective of investigating their contribution to the recovery of experimentally induced second-degree burns. For this purpose, male Wistar rats were randomized into six groups: a control group (CON) that received no treatment; a group treated with silver sulfadiazine ointment (SUL); a group treated with sericin cream (SER); a group treated with low-level laser photobiomodulation (LBP); a group treated with sulfadiazine and laser (SUL+LBP); and a group treated with sericin and laser (SER+LBP). Each group consisted of 20 animals, 12 weeks old and approximately 350g. The groups were subdivided, with half of the animals euthanized after 7 days (D7) and the other half after 14 days (D14) following lesion induction. The burn was caused by contact with a metal instrument previously heated in a direct flame with the anesthetized animal's skin for a period of 3 seconds. Macroscopic evaluation by photography, thermography by photothermography, and histomorphometry of intact and lesioned skin were performed. A systematic review with meta-analysis was also conducted, considering articles that report the use of photobiomodulation in burn treatment. For statistical analysis, the generalized linear models test was performed with p=0.05. No statistical differences were found regarding lesion area among the 7-day groups; however, there was a statistical difference (p<0.05) between the CON and LBP groups and the others, as they presented a reduction in burned area. There was a statistical difference between the AV0 and AV1 evaluations in the analysis of lesion surface temperature in the 7- and 14-day groups (p>0.05). However, there was no difference in the analysis of granulation tissue formation scale among any group. Regarding collagen deposition, the SER, LBP, SUL+LBP, and SER+LBP groups were different from the CON control group, with higher scores on the scale used (p<0.05); the SER+LBP group also presented a higher percentage of type I collagen, being statistically different from the other groups (p<0.05). In the molecular analyses of the 14-day groups, there was a reduction in TNFα, TBARS, and CAT concentrations (p<0.05), especially in the treatments combined with LBP, indicating a reduction in oxidative stress. The study pointed to an improvement in the tissue healing process, and further analyses could further elucidate the mechanisms of skin repair in the analyzed animals Publisher: Universidade Estadual do Oeste do Paraná Tipo do documento: Tese

ANÁLISE INSTITUCIONAL DA PSIQUIATRIA NA ORGANIZAÇÃO DO CUIDADO E NO TRABALHO MULTIPROFISSIONAL EM CENTROS DE ATENÇÃO PSICOSSOCIAL

Tue, 16 Sep 2025 00:00:00 GMT

Title: ANÁLISE INSTITUCIONAL DA PSIQUIATRIA NA ORGANIZAÇÃO DO CUIDADO E NO TRABALHO MULTIPROFISSIONAL EM CENTROS DE ATENÇÃO PSICOSSOCIAL Autor: Giacomini, Eduardo Primeiro orientador: Rizzotto, Maria Lucia Frizon Abstract: Introduction: The growing demands in the field of mental health and the transformations in care practices highlight tensions between different models of care. The persistence of the biomedical paradigm in community-based services challenges the principles of the Brazilian Psychiatric Reform and undermines the development of interdisciplinary approaches. Institutional analysis offers a theoretical-methodological framework capable of revealing instituted forces, instituting movements, and analyzers present in practices, allowing for an understanding of how certain rationalities are maintained or transformed within institutions. Objective: To analyze how psychiatry guides care practices and interprofessional relations within teams at psychosocial care centers (CAPS), based on the theoretical framework of Institutional Analysis. Methodology: This is a qualitative, exploratory study based on semi-structured interviews with six psychologists and six psychiatrists working in psychosocial care centers across different regions of Brazil. Data were analyzed using thematic content analysis, by Bardin, with interpretation grounded in Institutional Analysis, in dialogue with the field of collective health. Results and Discussion: Six thematic categories emerged from the interviews: 1. conceptions of mental health, 2. conceptions of mental illness, 3. the role of psychiatry, 4. conceptions of care, 5. foundations of effective care, and 6. conditions and challenges for multiprofessional collaboration. Psychiatry has been recognized as an institution that exerts influence over care practices and work dynamics, upholding biomedical and hierarchical rationalities — expressions of the instituted. The analyzers such as crisis management, diagnostic logic, and professional hierarchies reveal tensions and contradictions within the studied context. Meanwhile, instituting forces drive the redefinition of care, promote user autonomy, strengthen multiprofessional collaboration, and challenge medicalization. Final Considerations: The study reveals the institutional role of psychiatry within CAPS, whose biomedical hegemony shapes clinical practices, professional relationships, and modes of care organization. Although at times acknowledged as contributive and even expected by teams, this centrality tends to constrain broader perspectives, relegating psychosocial and collective approaches to a secondary place. In this context, tensions and ambiguities emerge: different professional groups, both medical and non-medical, reproduce hegemonic logic while simultaneously expressing resistance and openness to interdisciplinary and innovative practices. These disputes highlight possibilities for the reinvention of care and professional relations, underscoring the need for strategies that foster multiprofessional cooperation and critical reflection on the ways of acting and interacting within mental health services. Publisher: Universidade Estadual do Oeste do Paraná Tipo do documento: Tese

Desenvolvimento Neuropsicomotor de bebês nascidos de mães contaminadas e não contaminadas pelo vírus SARS-CoV-2 no período gestacional

Wed, 09 Jul 2025 00:00:00 GMT

Title: Desenvolvimento Neuropsicomotor de bebês nascidos de mães contaminadas e não contaminadas pelo vírus SARS-CoV-2 no período gestacional Autor: Santos, Alessandra Madalena Garcia Primeiro orientador: Viera, Cláudia Silveira Abstract: Introduction: A novel type of virus, named SARS-CoV-2, triggered the 2019 coronavirus disease (COVID-19), which was declared a pandemic by the World Health Organization in 2020. Other viral infections with maternal-fetal risks have previously been reported, such as the Zika virus, which led to an increase in cases of microcephaly in infants born to mothers infected during pregnancy. This highlights the importance of monitoring infants born to mothers infected with SARS-CoV-2 during pregnancy, as the long-term impacts on this group remain uncertain. This raises the question: do infants exposed to SARS-CoV-2 in utero exhibit alterations in neuropsychomotor development during the first years of life? Objective: To evaluate the neuropsychomotor development of infants born to mothers infected with SARS CoV-2 during pregnancy, compared to those born to uninfected mothers during the same period, between 18 and 24 months of age. Methods: This is a quantitative, epidemiological, analytical observational study with a cross-sectional design, conducted in the municipality of Cascavel, Paraná, Brazil. The sample was divided into two groups: Group 01, composed of 19 children born to mothers infected with SARS CoV-2 during pregnancy (Exposed Group - EG); and Group 02, composed of 31 children born to mothers who were not infected with SARS-CoV-2 (Non-Exposed Group - NEG). Participants were randomly selected from municipal health information systems covering the period from March 2020 to December 2021, and assessment appointments were scheduled accordingly. Data collection took place from October 2022 to September 2023 and involved a structured interview with the mother or legal guardian (including demographic, social, and health-related information), using a validated instrument. Neuropsychomotor development was assessed using the Bayley Scales of Infant and Toddler Development – Third Edition (Bayley-III) and the Ages and Stages Questionnaire – Third Edition (ASQ-3, Brazilian version). Data analysis was performed using the Statistical Package for the Social Sciences (SPSS) and JASP software. Statistical tests were selected according to data distribution and included Fisher’s Exact Test, Chi-Square Test with Yates’ correction, and Student’s T-test. Results: The characterization instrument used for the sample demonstrated a content validity index of 0.85, indicating strong content equivalence. When comparing the Bayley-III and ASQ-3 scales for assessing infant neuropsychomotor development, moderate correlations were observed between the "communication" domains (r = 0.535, p < 0.001). However, these findings were not sufficient to confirm equivalence between the two instruments. Neuropsychomotor development outcomes showed no statistically significant differences between the NEG and EG groups across both assessment tools (Bayley-III: p = 0.39; ASQ-3: p = 0.21 to 0.85 across domains). Conclusions: Infants born to mothers who tested positive for SARS-CoV-2 during pregnancy did not demonstrate significant neuropsychomotor developmental alterations between 18 and 24 months of age when compared to those born to SARS CoV-2 negative mothers. Publisher: Universidade Estadual do Oeste do Paraná Tipo do documento: Tese