https://tede.unioeste.br/handle/tede/586 2026-06-16T13:26:08Z https://tede.unioeste.br/handle/tede/8463 Title: Liofilização de produtos aquáticos: tendências científicas, desafios atuais e influência da geometria de corte na qualidade de filés de tilápia-do-Nilo (Oreochromis niloticus) Autor: Souza, Pauliana Leão de Primeiro orientador: Signor, Altevir Abstract: In this review, we synthesize the literature on the freeze-drying of aquatic products to analyze the current state of research on this topic worldwide. In total, 345 publications met the inclusion criteria. It was observed that, from 1958 onwards, the volume of published studies grew considerably, distributed across 181 journals in the areas of Analytical Chemistry, Biochemistry, and Food Science and Engineering. The journals Food Chemistry (6.96%), International Journal of Biological Macromolecules (2.90%), Journal of Food Science (2.90%), and Journal of the Science of Food and Agriculture (2.90%) concentrated the largest number of publications. The study of freeze-drying in aquatic products has sparked the interest of researchers in 51 countries. However, scientific output has been concentrated in China (21.74%) and the United States (8.70%). In contrast, publications originating from Oceania, Africa, and Central America have remained scarce. Furthermore, although the research covered 12 different types of raw materials, fish (64.68%) was the main target of the investigations. Among the fish species, Nile tilapia (Oreochromis niloticus) was the one with the greatest interest for the application of the freeze-drying method (7.20%) in the studies. There was a predominance of studies involving muscle tissues and their derivatives (41.13%) and protein biomolecules (23.38%). The focus of most of the research was related to the areas of Food Engineering (48.93%) and Analytical Chemistry (17.91%). Predominance observed in most of the countries analyzed. However, although the scope of the studies has changed over the years, most publications have remained in already established areas. Furthermore, research is needed to reduce energy costs and improve equipment, aiming to expand access to freeze-drying in regions where its use is still limited. In addition, it is essential to delve deeper into underexplored fields such as Animal Health and Genetics, as well as investigations into the freeze-drying of aquatic by-products, with the goal of adding value and ensuring the sustainability of the process. Publisher: Universidade Estadual do Oeste do Paraná Tipo do documento: Tese 2026-03-09T00:00:00Z https://tede.unioeste.br/handle/tede/8449 Title: Socioeconomia e qualidade de vida dos pescadores profissionais do entorno do Parque Nacional de Ilha Grande MS/PR, Brasil Autor: Yunes, Rosinara Virginia Ferreira Primeiro orientador: Kashiwaqui, Elaine Antoniassi Luiz Abstract: This research investigates the socioeconomic conditions and quality of life of professional fishers operating in the surroundings of Ilha Grande National Park, located in the Upper Paraná River Basin, a region marked by profound environmental transformations resulting from river damming and the establishment of protected areas. Developed in a multipaper format, the dissertation articulates two complementary empirical studies based on interviews with 59 professional fishers, combining descriptive analysis, content analysis, and multidimensional perceptual assessment. The first study characterizes the socioeconomic and productive profile of these fishers, highlighting the aging of the category, low educational attainment, economic dependence on fishing, declining income, and changes in fish composition associated with historical damming processes along the Paraná River. The second study deepens this analysis by evaluating fishers’ quality of life across economic, social, and environmental dimensions, comparing the fishers’ own perceptions with assessments of institutional governance. The findings reveal significant divergences between these rationalities, indicating that quality of life cannot be understood through isolated or exclusively institutional indicators, but rather as a multidimensional construct shaped by environmental, economic, and social factors, as well as by traditional fishing knowledge. By shedding light on tensions between environmental conservation, public policies, and traditional ways of life, this research contributes to the debate on professional fishing in protected areas and to the formulation of management strategies that are more responsive to the social realities of fishing communities. Publisher: Universidade Estadual do Oeste do Paraná Tipo do documento: Tese 2026-03-09T00:00:00Z https://tede.unioeste.br/handle/tede/8444 Title: Mediação educativa em trilhas interpretativas no Parque Nacional do Iguaçu: um relato de experiência em Capanema-PR Autor: Santos, Heloisa Ilkiu dos Primeiro orientador: Nyamien, Francy Rodrigues da Guia Abstract: This dissertation, developed within the Graduate Program in Environmental Sciences at the State University of Western Paraná, analyzes the educational mediation experience carried out between 2019 and 2020 on interpretive trails in Iguaçu National Park, in the Capanema sector, Paraná, a municipality bordering the Conservation Unit. The study examines the pedagogical design of the educational actions in light of the Park Management Plan, considering challenges related to the understanding of public use regulations, risk perception in sensitive areas, and the strengthening of territorial belonging. A qualitative, descriptive-analytical approach was adopted, based on the systematization of experience, field records, participant observation, and critical reflection. The results indicate that the pedagogical cycle of preparing, experiencing, and socializing favored a broader understanding of the ecological processes of the Atlantic Forest, strengthened low-impact behaviors, and contributed to the internalization of conservation regulations and to the recognition of the Park as a collective heritage. It is concluded that educational mediation, when territorialized and articulated with environmental governance, constitutes a strategic instrument for qualifying public use and protecting the Outstanding Universal Value of Iguaçu National Park. Publisher: Universidade Estadual do Oeste do Paraná Tipo do documento: Dissertação 2026-02-24T00:00:00Z https://tede.unioeste.br/handle/tede/8435 Title: Estudo in silico de inibidores da glicogênio sintase quinase 3 beta (GSK-3beta) Autor: Ribeiro, Maira Primeiro orientador: Melo, Eduardo Borges de Abstract: Alzheimer's disease (AD) is the leading cause of dementia worldwide and is characterized by the accumulation of β-amyloid (Aβ) plaques and the formation of intracellular neurofibrillary tangles. The enzyme GSK-3β plays a central role in these processes, making it a promising target for the development of new therapies. Given the limitations of currently available treatments, computer-aided drug design (CADD) methodologies were employed, including Quantitative Structure–Activity Relationship (QSAR) modeling, 2D similarity-based virtual screening, and structure-based drug design approaches. QSAR models were developed from a dataset of 60 pyrazolone derivatives described as GSK-3β inhibitors. The models were generated using two different approaches: (i) based on SMILES representations (1D/2D descriptors, via AlvaDesc/OCHEM) and (ii) based on DFT-optimized structures (electronic, topological, and geometric descriptors, via Dragon 6.0). These approaches resulted in two main models: D1, containing 12 descriptors (R² = 0.908; Q²LOO = 0.855), and O1, containing 10 descriptors (R² = 0.874; Q²LOO = 0.808). Both models underwent internal and external validation, demonstrating robustness, statistical significance, and good predictive performance. 2D similarity-based virtual screening (performed using SwissSimilarity) yielded 9,343 compounds, which were subsequently reduced to 16 hits based on the Tanimoto coefficient. In parallel, molecular docking screening (performed with PyRx) led to the selection of 28 compounds, which were subjected to consensus docking (GOLD); among these, three were selected for molecular dynamics simulations. The QSAR models were applied to the compounds obtained from 2D similarity screening to predict their biological activity. Pharmacokinetic evaluation (performed using the BOILED-Egg model) of the 19 compounds selected in conjunction with the other analyses, the results reinforced the selection of two promising candidates, compound J and compound 7178171, both showing potential to permeate the blood–brain barrier. These results highlight the potential of in silico approaches for identifying promising GSK-3β inhibitors, contributing to the development of new therapeutic strategies for AD. Publisher: Universidade Estadual do Oeste do Paraná Tipo do documento: Dissertação 2026-03-04T00:00:00Z