https://tede.unioeste.br/handle/tede/460 2026-08-07T17:32:14Z https://tede.unioeste.br/handle/tede/8588 Title: Fórmulas infantis prebióticas: caracterização físico-química, microbiológica e verificação do efeito prebiótico Autor: Soares, Mykelli De Andrade Santos Primeiro orientador: Bernardi, Daniela Miotto Abstract: Infant formulas (IF) constitute an important nutritional alternative for infants when breastfeeding is not possible, making it essential to ensure their physicochemical, microbiological, and functional quality. This study aimed to characterize prebiotic infant formulas intended for infants aged 0 to 6 months regarding their physicochemical composition, microbiological quality, and their ability to stimulate probiotic growth in vitro. Three commercial brands of IF supplemented with fructooligosaccharides (FOS) and galactooligosaccharides (GOS), acquired from retail stores in Cascavel, Paraná, Brazil, were evaluated. Physicochemical and microbiological analyses were performed on powdered and reconstituted formulas immediately after the package was opened and after storage periods at room temperature. The growth of Lactobacillus acidophilus in media supplemented with these formulas was also evaluated. The results demonstrated that the IF presented centesimal composition within the limits established by Brazilian legislation, although significant differences among brands and batches were observed in some parameters. Microbiological analyses showed the absence of pathogenic microorganisms of sanitary relevance, indicating satisfactory microbiological safety conditions throughout the evaluated period. A slight increase in mesophilic aerobic counts was observed during storage of the reconstituted formulas; however, the values remained within acceptable standards. Formulas supplemented with prebiotics promoted the growth of Lactobacillus acidophilus, demonstrating a potential in vitro prebiotic effect. It was concluded that the evaluated prebiotic infant formulas presented satisfactory physicochemical and microbiological quality, in addition to functional potential related to the stimulation of beneficial bacterial growth, reinforcing their importance as a nutritional alternative for infants. Publisher: Universidade Estadual do Oeste do Paraná Tipo do documento: Dissertação 2026-07-28T00:00:00Z https://tede.unioeste.br/handle/tede/8587 Title: Gradientes ambientais e delimitação das florestas subtropicais brasileiras: uma revisão sistemática. Autor: Quinto, Gabriela Gariani Primeiro orientador: Temponi, Lívia Godinho Abstract: The use of the term “subtropical” remains inconsistent in the Brazilian scientific literature, especially in the context of forest formations associated with the Atlantic Forest. In this study, we sought to identify which Brazilian forest formations have been classified as subtropical and to characterize the environmental gradients associated with these forests. To this end, a systematic literature review was conducted in the Scopus and Web of Science databases, yielding 372 records, of which 80 studies were included after applying the eligibility criteria. Based on these studies, geographic coordinates and information on climate, elevation, precipitation, and phytophysiognomy were compiled, supplemented by standardized edaphic data. Spatial analyses were also performed using interpolation, density estimation, and environmental suitability modeling via the MaxEnt algorithm. The studies focused primarily on the states of Paraná, Santa Catarina, and Rio Grande do Sul (94%), where the humid subtropical climates Cfa and Cfb predominate. The phytophysiognomies most frequently associated with the term were the Mixed Rainforest (42%) and the Seasonal Semideciduous Forest (23.5%), both within the Atlantic Forest region. Based on the data compiled in the review, areas classified as subtropical are associated with annual mean temperatures between 12.2 and 21.6 °C, annual precipitation between 1,181 and 3,300 mm, and elevations of up to approximately 1,668 m. The results demonstrate that the term “subtropical forest,” as used in the analyzed literature, corresponds to a quantifiable environmental envelope defined by specific combinations of climatic, topographic, and phytophysiognomic attributes, and not necessarily to the official delimitation or actual distribution of a biome within Brazilian territory. Publisher: Universidade Estadual do Oeste do Paraná Tipo do documento: Dissertação 2026-02-26T00:00:00Z https://tede.unioeste.br/handle/tede/8581 Title: O anti-intelectualismo na escola pública no contexto neoliberal: uma análise do novo Ensino Médio. Autor: Lima, Carlos Henrique Lacerda de Primeiro orientador: Silva, João Carlos da Abstract: This dissertation analyzes how the New High School (NEM), by introducing training tracks and subjects such as the “Life Project,” reinforces a logic of individual responsibility and market-driven training to the detriment of reflective education that serves the interests of the working class. The research stems from the need to understand how discourses that devalue scientific knowledge and critical thinking are articulated with educational policies focused on technical and market-oriented training. The research problem consists of investigating which economic, social, political, cultural, and ideological factors have conditioned the spread of anti-intellectualism in public schools. The objective is to investigate how these factors sustain the advancement of anti-intellectualism in education. The methodology is bibliographic and documentary, emphasizing the analysis of classic and contemporary authors discussing education, intellectuality, ideology, and neoliberalism, in addition to the content provided by the State of Paraná to public school teachers for the “Life Project” component. The analysis of the state network’s teaching materials reveals the insertion of meritocracy, coaching, and self-management discourses, which replace systematized scientific knowledge with market language, emptying the school’s social function. Anti-intellectualism thrives in political and social environments and propagates under the aegis of capital and neoliberalism. Thus, it is necessary to resort to neoliberal classics and their theories and narratives about education within the public school scenario. It is essential to debate the way capital precaritizes the public school, rendering it reproductive and alienating. The New High School represents a training project aimed at market adaptation rather than critical and emancipatory education, deepening inequalities and weakening the intellectual perspective of training. As a counterpoint, the research presents Historical-Critical Pedagogy and the Unitary School as pathways to an education that is both intellectual and emancipatory, focused on the interests of the working class, which could cease the exploitation and inequalities perpetrated by neoliberal capitalism. Publisher: Universidade Estadual do Oeste do Paraná Tipo do documento: Dissertação 2026-05-29T00:00:00Z https://tede.unioeste.br/handle/tede/8580 Title: Desenvolvimento de complexos de inclusão bosentana-ciclodextrina e avaliação das características biofarmacêuticas. Autor: Webler, Emanuelle Menegazzo Primeiro orientador: Rosa, Mauricio Ferreira da Abstract: Pulmonary hypertension is a condition that affects the respiratory system, causing fatigue and exercise intolerance. In addition to being an incurable disease, its evolution is fast, and there are few effective options for treatment. The need for drugs to treat this disease and the growing interest of the medical class the knowledge of this disease prompted the study in this area, in order to search for therapeutic enhancement of currently available drugs for the treatment of pulmonary arterial hypertension. Because the bosentan a low solubility and bioavailability of drug, is interesting that pharmacotechnical methods are developed to provide improved absorption of this drug and potentiation of pharmacological activity of the therapeutic dose approved for the treatment of pulmonary hypertension. One of the available techniques for improving solubility and bioavailability of drugs is complexation with cyclodextrins used successfully in low aqueous solubility drugs. Thus, the intention of developing bosentan inclusion complexes with cyclodextrins is to promote better therapeutic use, increasing the effectiveness of the pharmacological treatment of patients with pulmonary hypertension. This research proposes the formation of bosentan inclusion complexes and cyclodextrins to increase drug solubility and improve the bioavailability of the drug, providing a differentiated ability to potentiate the treatment of pulmonary hypertension, can promote drug absorption, by optimizing the therapeutic effect and improving the quality of life of patients. The inclusion complex was prepared by several techniques, in solution, by physical mixing and spray-drier, evaluating the physico-chemical changes and characterization of the complex through the kinetic techniques, the stoichiometry of complexation, the solubility isotherms, spectrophotometry UV-VIS, solubility, DSC, TGA, infrared spectroscopy, electron microscopy in bright field and polarized light, apparent dissolution and dissolution profile. The results showed the formation of the inclusion complex due to changes in the characteristic peaks of the raw materials and increasing solubility, taking into consideration the conditions evaluated. The inclusion complex showed higher water solubility that the isolated bosentan, reinforcing the possibility that a formulation with the inclusion complex may have greater bioavailability in the organism. Publisher: Universidade Estadual do Oeste do Paraná Tipo do documento: Dissertação 2015-12-09T00:00:00Z