TEDE Collection:

Repercussões mentais e físicas em idosos após internação na Unidade de terapia intensiva por COVID-19

2026-05-15T13:23:57Z

Title: Repercussões mentais e físicas em idosos após internação na Unidade de terapia intensiva por COVID-19 Autor: Ibrahim, Saluhu Primeiro orientador: Rodrigues, Rosa Maria Abstract: The Covid-19 virus is highly contagious and easily penetrates the airways, initially attacking the lungs and spreading to other organs, with a high potential to cause damage and death. Common symptoms include headaches, sore throats, flu-like symptoms, fever, cough, fatigue, dyspnea, tiredness, loss of taste, nasal congestion, nasal discharge, nausea and vomiting, and digestive problems such as diarrhea. Furthermore, it has the potential to cross the blood-brain barrier, leading to neural disturbances that can persist for days, weeks, months, or even longer, resulting in various problems such as depression, anxiety, forgetfulness, and insomnia. The elderly are the most affected due to immunodeficiency and chronic conditions. The objective of this study was to understand the perception of elderly individuals admitted to the Intensive Care Unit due to Covid-19 infection regarding the mental and physical repercussions after infection. Methodology: This is an exploratory, descriptive, and field study with a qualitative approach, conducted with elderly individuals who were admitted to the Intensive Care Unit of a university hospital located in the western region of Paraná. Data was retrieved from the electronic medical records of elderly individuals diagnosed with and admitted to the Intensive Care Unit due to Covid-19. Semi- structured interviews were conducted, recorded with an MP3 player, validated by the participants, transcribed, and analyzed using Bardin's method. Results: The study included 11 participants aged between 64 and 80 years. The findings indicated that the majority of the elderly were female (54.54%), aged between 70 and 80 years (63.64%), white (54.55%), married (45.45%), with completed primary education (90.90%), retired, and with an income equivalent to one minimum wage (90.90%). All participants reported some type of impairment resulting from Covid-19, with varying impacts, some presenting more pronounced consequences in the mental sphere, while others had more significant repercussions in the physical aspect. Final considerations: The study evidenced psychological, emotional and physical changes caused by Covid-19. Therefore, it is imperative to direct specialized attention to this population to mitigate the long-term consequences. Publisher: Universidade Estadual do Oeste do Paraná Tipo do documento: Dissertação

O Itinerário terapêutico de pessoas com obesidade no sus: uma experiência na região oeste do Paraná

2026-04-23T17:15:17Z

Title: O Itinerário terapêutico de pessoas com obesidade no sus: uma experiência na região oeste do Paraná Autor: Oliveira, José Joacy Rabelo de Primeiro orientador: Araújo, Allan Cezar Faria Araújo Abstract: Introduction: The increasing prevalence of overweigh and obesity constitutes one of the main challenges for contemporary public health, compromising health systems. In this context, understanding the therapeutic itinerary of obese individuals referred for bariatric surgery can contribute to improvements in care practies and multidisciplinary follow-up strategies. Objectives: To analyze the characteristics of the therapeutic itinerary of individuals indicated for bariatric surgery, attended by a specialized service of a public teaching hospital in the western region of Paraná; To describe current situation of obesity in the municipalities that refer patients to the bariatric surgery and obesity service; To evaluate the relevance of interdisciplinay follow-up in the tratament of obesity; And to identify patients perceptions of facilitators and barries encountered along the preoperative therapeutic itinerary. Methods: This is a mixed-methods study (qualitative and quantitative), based on the inductive method, with an observational cohort design and longitudinal charater. Quantitative data were obtaained from the monitoring sreadsheets of users participating in the bariatric surgery and obesity service and analyzed using Quantum GIS softwere. Qualitative data derived from semistructured interviews with 19 participants followed for 12 months, verified according to the content analysis technique proposed by Bardin, with the support of TAMS Analyser software. Results and discussion: the qualitative analysis allowed us to understand the current obesity status of the studied group, it is clinical and social aspects. From the analysis of the interviews, five thematic categories were identified: contemporary eating habits; physical aactivity in daily digital life; emotions and self-image; social determinants of health; and access to health care. After this analysis, we can identify errors and success in the therapeutic itinerari, which helps us reflect on what measures could be tken to improve the treatment of obese patients in the western region of Paraná. Publisher: Universidade Estadual do Oeste do Paraná Tipo do documento: Dissertação

Oclusão seletiva e permanente da artéria cerebral média em ratos: uma abordagem experimental para o estudo de déficits motores e de memória espacial

2026-04-15T12:36:43Z

Title: Oclusão seletiva e permanente da artéria cerebral média em ratos: uma abordagem experimental para o estudo de déficits motores e de memória espacial Autor: ALMEIDA, Leandro Pelegrini de Primeiro orientador: Balbo, Sandra Lucinei Abstract: Introduction: Ischemic stroke (IS) has high clinical relevance and demands experimental approaches capable of enabling the development of novel adjuvant therapies. Due to the similarity of cerebral vascular anatomy to that of humans, rats are widely used as experimental models of IS. However, there remains a need for methods that generate an ischemic environment more closely resembling that observed in humans, using an approach that prioritizes selective occlusion of the middle cerebral artery (MCA), the vessel most commonly employed in experimental occlusion models. Objective: To establish a reproducible method for performing craniectomy followed by permanent and selective occlusion of the middle cerebral artery (MCA) in rats, aiming to standardize the procedure, reduce technical challenges, and enable its application in studies of motor deficits and spatial memory impairment. Methods: Twenty-eight Wistar rats (N = 28) were equally allocated into two groups: a craniectomy-only group (SHAM) and a craniectomy combined with selective MCA occlusion group (SMCAO). On postoperative days 7 and 8, animals underwent the postural test and the object location recognition memory test, respectively. After euthanasia, brain tissues were sectioned and processed using Nissl staining. A detailed surgical protocol was developed to demonstrate the feasibility and effectiveness of the method, encompassing preoperative preparation, anesthesia, positioning, craniectomy, MCA occlusion, and closure. Results: The method produced significant deficits in the SMCAO group, as evidenced by the postural test (p = 0.015) and the object location recognition memory test (p < 0.001). Histological examination confirmed the selectivity of the approach, with injury localized to regions associated with the hippocampal network—such as the perirhinal, entorhinal, and piriform cortices—and the external capsule, while deeper brain structures remained preserved. Conclusions: This protocol proved to be a reproducible and effective method for inducing selective MCA ischemia in rats. It represents a valid and technically accessible experimental tool for studies investigating the pathophysiological mechanisms and potential therapeutic strategies in ischemic stroke. Publisher: Universidade Estadual do Oeste do Paraná Tipo do documento: Dissertação

ASSOCIAÇÃO ENTRE A PREVALÊNCIA DE LESÕES POR PRESSÃO EM PACIENTES CRÍTICOS E SUPLEMENTAÇÃO ALIMENTAR HIPERPROTEICA: ESTUDO TRANVERSAL

2026-03-03T19:43:48Z

Title: ASSOCIAÇÃO ENTRE A PREVALÊNCIA DE LESÕES POR PRESSÃO EM PACIENTES CRÍTICOS E SUPLEMENTAÇÃO ALIMENTAR HIPERPROTEICA: ESTUDO TRANVERSAL Autor: Camargo, Nathan Iori Primeiro orientador: Costa, Rose Meire Abstract: Pressure injuries (PI) are localized damage to the skin and underlying tissues, caused by sustained pressure of the epidermis against an external surface or by the combination of pressure and shear forces, and may progress to tissue ischemia, necrosis, and, in severe cases, ulcers and amputations. Hospitalized individuals, especially those admitted to intensive care units (ICUs), are particularly susceptible to these injuries due to reduced mobility, nutritional impairment, and compromised health status. This results in prolonged hospital stays, increased costs, and higher morbidity and mortality. Preventive strategies include systematic risk assessment and specific nutritional care. In this context, nutritional supplementation—especially hyperproteic formulations—has been used as an adjuvant nutritional strategy with potential to contribute to the prevention of PI. This cross-sectional study aimed to analyze the association between PI prevalence and hyperproteic nutritional supplementation in critically ill patients. Data were collected between February and October 2025 through the analysis of secondary data from patients receiving nasoenteral tube feeding who were classified as being at high risk for PI development according to the Braden scale, during ICU hospitalization at a public teaching hospital in western Paraná, Brazil. The sample consisted of electronic medical record data from 152 patients, including sociodemographic, clinical, nutritional, and laboratory variables, analyzed using Jamovi software version 2.4.8. The sample had a mean age of 54.2 ± 19.2 years, with a predominance of adults (56%), males (69%), and a PI prevalence of 44%, with a mean time to injury onset of 9 ± 2.9 days. Neurology was the most frequent medical specialty (49%), and traumatic brain injury was the main cause of hospitalization (21%). Regarding comorbidities, hypertension (37%) and diabetes (23%) were the most prevalent. Among patients who received nutritional supplementation, most did not develop PI (71%, n = 54), and those who did (29%, n = 22) had a mean time of 11 ± 2.4 days until injury onset. In contrast, among patients who did not receive supplementation, 59% (n = 45) developed PI during hospitalization, with a mean time of 8 ± 2.7 days until injury development. These descriptive findings were corroborated by adjusted logistic regression analysis, in which non-use of nutritional supplementation was associated with a higher likelihood of developing PI during hospitalization (adjusted OR = 3.45; 95% CI: 1.54–7.75; p = 0.003). Additionally, achievement of nutritional targets was identified as a protective factor associated with a lower likelihood of PI occurrence, independently of supplement use (OR = 0.18; 95% CI: 0.08–0.39; p < 0.001). Longitudinal analysis of laboratory parameters demonstrated progressive improvement in total protein, albumin, and globulin levels throughout hospitalization, predominantly associated with achievement of nutritional targetsIn conclusion, hyperproteic supplementation was associated with a lower occurrence of PI in critically ill patients, reflecting its preferential use in individuals with greater clinical severity and nutritional risk. Moreover, achievement of nutritional targets was consistently associated with a lower prevalence of PI and improvement in laboratory parameters, reinforcing the central role of adequate nutritional support in the care of critically ill patients. Publisher: Universidade Estadual do Oeste do Paraná Tipo do documento: Dissertação