TEDE Collection:https://tede.unioeste.br/handle/tede/6022024-03-29T01:31:59Z2024-03-29T01:31:59ZPreparação e caracterização de microesfera de etilcelulose com o ativo metforminaFarias, Alessandra Zucunellihttps://tede.unioeste.br/handle/tede/70592024-03-01T23:48:15Z2023-10-06T00:00:00ZTitle: Preparação e caracterização de microesfera de etilcelulose com o ativo metformina
Autor: Farias, Alessandra Zucunelli
Primeiro orientador: Bariccatti, Reinaldo Aparecido
Abstract: The present work describes the preparation and characterization of the formation of microspheres using the polymer ethylcellulose with the drug metformin. Due to the increase in the search for this form of administration for medicines where the demand is to achieve a prolonged release of the drug and the protection of the substance mainly from degradation. The in vitro evaluation carried out using spectroscopic techniques of ethylcellulose microspheres with the drug metformin demonstrated promising characteristics for the percentages of 3 and 5% where release monitoring showed prolonged behavior for the drug.
Publisher: Universidade Estadual do Oeste do Paraná
Tipo do documento: Dissertação2023-10-06T00:00:00ZEstudo da degradação forçada de Gliclazida sob a forma de comprimidos e validação de método analítico indicativo de estabilidade empregando HPLC-DADCoradi Junjior, Olairhttps://tede.unioeste.br/handle/tede/69112023-11-22T23:38:50Z2023-10-02T00:00:00ZTitle: Estudo da degradação forçada de Gliclazida sob a forma de comprimidos e validação de método analítico indicativo de estabilidade empregando HPLC-DAD
Autor: Coradi Junjior, Olair
Primeiro orientador: Campos, Elvio Antônio de
Abstract: To market a medicine, it must undergo quality tests to assess its safety and efficiency. Therefore, analytical analyzes are carried out to evaluate quality, the main ones being: identification, assay, degradation products, disintegration, friability, dissolution, uniformity of content and microbiological analysis. Therefore, in the study an analytical method was developed by HPLC- DAD, quantifying the content and impurities in the same chromatographic run. After development tests, chromatographic parameters were defined for validation. The chromatographic column used is a Waters XbridgeTM C18 (250 x 4.6 mm, 3.5 µm) at a temperature of 30 ºC. The system has an elution gradient, with the mixture of 0.1% Triethylamine solution in purified water with the pH adjusted to 3.8 with phosphoric acid and Acetonitrile. The mobile phase flow rate was 1.0 mL min-1, with detection at 235 nm, in an analytical run of 50 minutes. Validation of the analytical method followed RDC 166/2017 of ANVISA, harmonized with ICH. In the statistical evaluation of Linearity, both the dosing method and the degradation product method were found to be linear. The dosing method was accurate, with a DPR of 0.6%. Likewise for non-specific impurities, where a DPR of 2% was observed for the low and high level, 3% for the medium level. Impurity G, for the low level the DPR was 3%, at the medium level 6% and at the high level 4%. As for Impurity A, at the low level the DPR was 4%, for the medium and high level it was 3%. In Accuracy, the dosing method showed an average recovery of 100% for the low and medium level, for the high level it was 99%. For non-specific impurities, the average recovery was 95% for the low level, 100% for the medium level and 101% for the high level. Impurity G obtained 102% for the low level, 96% for the medium level and 94% for the high level of medium recovery. Likewise, Impurity A obtained 101% for the low level, 97% for the medium level and 96% for the high level. Therefore, the methods proved to be precise, exact and linear in the working range and for impurities, the limit of quantification was adequate. In Selectivity, the acid hydrolysis stress condition resulted in a decay of close to 10% in 2 hours of exposure. Oxidation by metal ions caused a decay of approximately 15% after 6 hours of exposure. The other stress conditions of basic hydrolysis and peroxide oxidation showed decay after 10 days of exposure and for the physical stress conditions (thermal, humid and actinic) there was no degradation in 10 days.
Publisher: Universidade Estadual do Oeste do Paraná
Tipo do documento: Dissertação2023-10-02T00:00:00ZObtenção e caracterização físico-química de membranas poliméricas de etilcelulose incorporadas com liga de selênio-fósforo para ensaio de atividade fotocatalíticaMarasca, Patícia Márciahttps://tede.unioeste.br/handle/tede/69062023-11-22T17:51:56Z2023-08-04T00:00:00ZTitle: Obtenção e caracterização físico-química de membranas poliméricas de etilcelulose incorporadas com liga de selênio-fósforo para ensaio de atividade fotocatalítica
Autor: Marasca, Patícia Márcia
Primeiro orientador: Stolf, Sandro Fernando
Abstract: Polymeric membranes incorporated with chalcogenide alloys constitute a promising strategy for heterogeneous photocatalysis, leveraging the electron-hole photogeneration property. This work presents a study regarding the production and characterization of ethylcellulose polymeric membranes incorporated with selenium-phosphorus chalcogenide alloy (80:20) for use in photocatalytic activity assays. The alloy was produced using mechanical milling, and the membranes were synthesized through electrospinning. The membrane characterization was carried out using Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD), Contact Angle and Photoacoustic Spectroscopy (PAS). The study enabled the incorporation of the semiconductor alloy into the polymeric matrix at concentrations of 6%, 8%, and 10% (w/w), resulting in nanoscale fiber formation and optical absorption in the near-infrared region. Additionally, an increase in the fusion enthalpy and crystallinity of the membranes was observed with the increasing concentration of the semiconductor alloy. As a result, the photodegradation study allowed a reduction of up to 76% of methylene blue dye after 720 minutes of reaction, demonstrating that the produced materials hold significant potential for application in the field of photocatalysis.
Publisher: Universidade Estadual do Oeste do Paraná
Tipo do documento: Dissertação2023-08-04T00:00:00ZEfeito da concentração de plastificante em revestimentos comestíveis à base de blendas de poli(álcool vinílico) (PVA) e amido catiônico (CS)Petry, Jaiane Maiarahttps://tede.unioeste.br/handle/tede/68372023-10-05T12:09:43Z2023-07-05T00:00:00ZTitle: Efeito da concentração de plastificante em revestimentos comestíveis à base de blendas de poli(álcool vinílico) (PVA) e amido catiônico (CS)
Autor: Petry, Jaiane Maiara
Primeiro orientador: Dragunski, Douglas Cardoso
Abstract: Films based on poly(vinyl alcohol) (PVA) and cationic starch (CS) were combined with different percentages of sorbitol (S) to evaluate the effect of the plasticizer on the properties of the films. FTIR and DRX analyzes confirmed the interaction between them. However, SEM micrographs confirmed the formation of sorbitol crystals on the surface of the films. These crystals became more evident with increasing amount of sorbitol. The polymer/sorbitol mixture is stable for a short period. The mixtures showed low values of water vapor transmission rate, reaching (7.703 ± 0.00) g h-1 m-2 and low solubility values for films containing higher amounts of CS. The lack of statistical differences in most parameters suggests that increasing the amount of sorbitol does not promote any significant gain in percentages greater than 15% m/m. As a coating, the mixture composed of 75% PVA, 25% CS and 15% S successfully reduced moisture loss in the acerolas, and preserved the bright red color of the fruits for longer periods. In addition, the coating led to a more homogeneous maturation, and increased the shelf life of the acerolas by one day (temperature of 25ºC). This confirms the suitability of this mixture for food coating purposes.
Publisher: Universidade Estadual do Oeste do Paraná
Tipo do documento: Dissertação2023-07-05T00:00:00Z